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Mechanisms of Phosphine Toxicity
Joint Authors
Ebert, Paul R.
Bhattacharya, Ishita
Tuck, Andrew G.
Schlipalius, David I.
Nath, Nisa S.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Fumigation with phosphine gas is by far the most widely used treatment for the protection of stored grain against insect pests.
The development of high-level resistance in insects now threatens its continued use.
As there is no suitable chemical to replace phosphine, it is essential to understand the mechanisms of phosphine toxicity to increase the effectiveness of resistance management.
Because phosphine is such a simple molecule (PH3), the chemistry of phosphorus is central to its toxicity.
The elements above and below phosphorus in the periodic table are nitrogen (N) and arsenic (As), which also produce toxic hydrides, namely, NH3 and AsH3.
The three hydrides cause related symptoms and similar changes to cellular and organismal physiology, including disruption of the sympathetic nervous system, suppressed energy metabolism and toxic changes to the redox state of the cell.
We propose that these three effects are interdependent contributors to phosphine toxicity.
American Psychological Association (APA)
Nath, Nisa S.& Bhattacharya, Ishita& Tuck, Andrew G.& Schlipalius, David I.& Ebert, Paul R.. 2011. Mechanisms of Phosphine Toxicity. Journal of Toxicology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476129
Modern Language Association (MLA)
Nath, Nisa S.…[et al.]. Mechanisms of Phosphine Toxicity. Journal of Toxicology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-476129
American Medical Association (AMA)
Nath, Nisa S.& Bhattacharya, Ishita& Tuck, Andrew G.& Schlipalius, David I.& Ebert, Paul R.. Mechanisms of Phosphine Toxicity. Journal of Toxicology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476129
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476129