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Nucleocytoplasmic Shuttling of Cytoskeletal Proteins : Molecular Mechanism and Biological Significance
Joint Authors
Kumeta, Masahiro
Hejna, James
Takeyasu, Kunio
Yoshimura, Shige H.
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes.
Nuclear complexes such as these are involved in both basal and adaptive nuclear functions.
In addition to nuclear import via classical nuclear transport pathways or passive diffusion, some large cytoskeletal proteins spontaneously migrate into the nucleus in a karyopherin-independent manner.
The balance of nucleocytoplasmic distribution of such proteins can be altered by several factors, such as import versus export, or capture and release by complexes.
The resulting accumulation or depletion of the nuclear populations thereby enhances or attenuates their nuclear functions.
We propose that such molecular dynamics constitute a form of cytoskeleton-modulated regulation of nuclear functions which is mediated by the translocation of cytoskeletal components in and out of the nucleus.
American Psychological Association (APA)
Kumeta, Masahiro& Yoshimura, Shige H.& Hejna, James& Takeyasu, Kunio. 2011. Nucleocytoplasmic Shuttling of Cytoskeletal Proteins : Molecular Mechanism and Biological Significance. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476178
Modern Language Association (MLA)
Kumeta, Masahiro…[et al.]. Nucleocytoplasmic Shuttling of Cytoskeletal Proteins : Molecular Mechanism and Biological Significance. International Journal of Cell Biology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-476178
American Medical Association (AMA)
Kumeta, Masahiro& Yoshimura, Shige H.& Hejna, James& Takeyasu, Kunio. Nucleocytoplasmic Shuttling of Cytoskeletal Proteins : Molecular Mechanism and Biological Significance. International Journal of Cell Biology. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-476178
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476178