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Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease : Clinical and Neurochemical Correlates
Joint Authors
Aarsland, Dag
Londos, Elisabet
Mulugeta, Ezra
Ballard, Clive G.
Blennow, kaj
Hansson, Oskar
Minthon, Lennart
Skogseth, Ragnhild
Zetterberg, Henrik
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
We measured cerebrospinal fluid (CSF) levels of the soluble isoforms of amyloid precursor protein (APP; sAPPα sAPPβ) and other CSF biomarkers in 107 patients with Alzheimer's disease (AD), dementia with Lewy body dementia (DLB), Parkinson's disease dementia (PDD), and normal controls (NC) using commercial kits.
DLB and PDD were combined in a Lewy body dementia group (LBD).
No differences were observed in sAPPα and sAPPβ levels between the groups.
Significant correlations were observed between sAPPα and sAPPβ and between sAPPβ and Mini-Mental State Examination scores in the total group analysis as well as when LBD and AD groups were analyzed separately.
sAPPα and sAPPβ levels correlated with Aβ38, Aβ40, Aβ42, and Tau in the LBD group.
In AD, sAPPα correlated with p-Tau and sAPPβ with Aβ40.
The differential association between sAPPα and sAPPβ with Aβ and Tau species between LBD and AD groups suggests a possible relationship with the underlying pathologies in LBD and AD.
American Psychological Association (APA)
Mulugeta, Ezra& Londos, Elisabet& Hansson, Oskar& Ballard, Clive G.& Skogseth, Ragnhild& Minthon, Lennart…[et al.]. 2011. Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease : Clinical and Neurochemical Correlates. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476184
Modern Language Association (MLA)
Mulugeta, Ezra…[et al.]. Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease : Clinical and Neurochemical Correlates. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-476184
American Medical Association (AMA)
Mulugeta, Ezra& Londos, Elisabet& Hansson, Oskar& Ballard, Clive G.& Skogseth, Ragnhild& Minthon, Lennart…[et al.]. Cerebrospinal Fluid Levels of sAPPα and sAPPβ in Lewy Body and Alzheimer's Disease : Clinical and Neurochemical Correlates. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-476184
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476184