The Effect of Inflammatory Cytokines in Alcoholic Liver Disease
Joint Authors
Yoshiji, Hitoshi
Moriya, Kei
Takaya, Hiroaki
Kawaratani, Hideto
Noguchi, Ryuichi
Fukui, Hiroshi
Fujimoto, Masao
Namisaki, Tadashi
Douhara, Akitoshi
Tsujimoto, Tatsuhiro
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alcohol is the most common cause of liver disease in the world.
Chronic alcohol consumption leads to hepatocellular injury and liver inflammation.
Inflammatory cytokines, such as TNF-α and IFN-γ, induce liver injury in the rat model of alcoholic liver disease (ALD).
Hepatoprotective cytokines, such as IL-6, and anti-inflammatory cytokines, such as IL-10, are also associated with ALD.
IL-6 improves ALD via activation of the signal transducer and activator of transcription 3 (STAT3) and the subsequent induction of a variety of hepatoprotective genes in hepatocytes.
IL-10 inhibits alcoholic liver inflammation via activation of STAT3 in Kupffer cells and the subsequent inhibition of liver inflammation.
Alcohol consumption promotes liver inflammation by increasing translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells through the LPS/Toll-like receptor (TLR) 4 pathways.
Oxidative stress and microflora products are also associated with ALD.
Interactions between pro- and anti-inflammatory cytokines and other cytokines and chemokines are likely to play important roles in the development of ALD.
The present study aims to conduct a systemic review of ALD from the aspect of inflammation.
American Psychological Association (APA)
Kawaratani, Hideto& Tsujimoto, Tatsuhiro& Douhara, Akitoshi& Takaya, Hiroaki& Moriya, Kei& Namisaki, Tadashi…[et al.]. 2013. The Effect of Inflammatory Cytokines in Alcoholic Liver Disease. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476199
Modern Language Association (MLA)
Kawaratani, Hideto…[et al.]. The Effect of Inflammatory Cytokines in Alcoholic Liver Disease. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476199
American Medical Association (AMA)
Kawaratani, Hideto& Tsujimoto, Tatsuhiro& Douhara, Akitoshi& Takaya, Hiroaki& Moriya, Kei& Namisaki, Tadashi…[et al.]. The Effect of Inflammatory Cytokines in Alcoholic Liver Disease. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476199
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476199