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Antiapoptotic Effects of EGb 761
Joint Authors
Jiménez-Anguiano, Anabel
Sotelo, Julio
Cruz-Salgado, Arturo
Trejo-Solís, Cristina
Serrano-García, Norma
Mares-Sámano, José Juan
Pedraza-Chaverri, José
Orozco-Ibarra, Marisol
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-29
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Ginkgo biloba extracts have long been used in Chinese traditional medicine for hundreds of years.
The most significant extract obtained from Ginkgo biloba leaves has been EGb 761, a widely used phytopharmaceutical product in Europe.
EGb 761 is a well-defined mixture of active compounds, which contains two main active substances: flavonoid glycosides (24–26%) and terpene lactones (6–8%).
These compounds have shown antiapoptotic effects through the protection of mitochondrial membrane integrity, inhibition of mitochondrial cytochrome c release, enhancement of antiapoptotic protein transcription, and reduction of caspase transcription and DNA fragmentation.
Other effects include the reduction of oxidative stress (which has been related to the occurrence of vascular, degenerative, and proliferative diseases), coupled to strong induction of phase II-detoxifying and cellular defense enzymes by Nrf2/ARE activation, in addition to the modulation of transcription factors, such as CREB, HIF-1α, NF-κB, AP-1, and p53, involved in the apoptosis process.
This work reviews experimental results about the antiapoptotic effects induced by the standardized extract of Ginkgo biloba leaves (EGb 761).
American Psychological Association (APA)
Serrano-García, Norma& Pedraza-Chaverri, José& Mares-Sámano, José Juan& Orozco-Ibarra, Marisol& Cruz-Salgado, Arturo& Jiménez-Anguiano, Anabel…[et al.]. 2013. Antiapoptotic Effects of EGb 761. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-476238
Modern Language Association (MLA)
Serrano-García, Norma…[et al.]. Antiapoptotic Effects of EGb 761. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-476238
American Medical Association (AMA)
Serrano-García, Norma& Pedraza-Chaverri, José& Mares-Sámano, José Juan& Orozco-Ibarra, Marisol& Cruz-Salgado, Arturo& Jiménez-Anguiano, Anabel…[et al.]. Antiapoptotic Effects of EGb 761. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-476238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476238