Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma
Joint Authors
Kim, Yong-Beom
Kim, Haeryoung
Kim, Min A
Song, Yong-Sang
Kim, Mi-Kyung
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Epithelial-mesenchymal transition (EMT) has been suggested to contribute to tumor progression and acquisition of therapeutic resistance.
To assess the clinical significance of EMT-associated proteins, we evaluated the expression of Snail and Slug, the key regulators of EMT, in the primary ovarian cancer samples (n=103) by immunohistochemistry.
Snail was differentially expressed according to the histologic subtype (P=0.001) and was predominantly expressed in serous and endometrioid types.
In the serous and endometrioid adenocarcinomas, the expression of Snail remained high across the stage and grade, suggesting its role in the early phase of carcinogenesis.
However, the expression of Snail and Slug was not related to chemoresistance and poor prognosis and did not serve as independent predictive or prognostic marker.
American Psychological Association (APA)
Kim, Mi-Kyung& Kim, Min A& Kim, Haeryoung& Kim, Yong-Beom& Song, Yong-Sang. 2014. Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-476243
Modern Language Association (MLA)
Kim, Mi-Kyung…[et al.]. Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-476243
American Medical Association (AMA)
Kim, Mi-Kyung& Kim, Min A& Kim, Haeryoung& Kim, Yong-Beom& Song, Yong-Sang. Expression Profiles of Epithelial-Mesenchymal Transition-Associated Proteins in Epithelial Ovarian Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-476243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476243