Determination of Zalcitabine in Medicaments by Differential Pulse Voltammetry
Joint Authors
Moreira, Josino Costa
Leandro, Katia Christina
Mardini Farias, Pércio Augusto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The zalcitabine (ddC) has been extensively used in the treatment of HIV patients due to its antiretroviral activity.
The quality control of this active principle in medications is of outstanding importance to public health.
The principal objective of the current study was the development of an alternative analytical methodology for the zalcitabine determination using a voltammetric process.
The zalcitabine gives a reduction peak (at -1.22 V versus Ag/AgCl) at the hanging mercury drop electrode (HMDE).
The differential pulse voltammetric response is evaluated with respect to the scan rate (20 mV/s), pulse amplitude (50 mV), support electrolyte (Clark-Lubs buffer), pH (2.0), and other variables.
The response is linear over the 10.0 to 28.0 mg/L (47 to 133 μM) concentration range, and the detection limit is 2.08 mg/L.
The validation of this method was realized using a governmental Brazilian document (Inmetro, 2007) and the results are reported for medication drugs.
American Psychological Association (APA)
Leandro, Katia Christina& Moreira, Josino Costa& Mardini Farias, Pércio Augusto. 2013. Determination of Zalcitabine in Medicaments by Differential Pulse Voltammetry. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476251
Modern Language Association (MLA)
Leandro, Katia Christina…[et al.]. Determination of Zalcitabine in Medicaments by Differential Pulse Voltammetry. Journal of Pharmaceutics No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-476251
American Medical Association (AMA)
Leandro, Katia Christina& Moreira, Josino Costa& Mardini Farias, Pércio Augusto. Determination of Zalcitabine in Medicaments by Differential Pulse Voltammetry. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476251