Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone : A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection
Joint Authors
Dunn, Jack
Agarwal, Amit
Buadu, Lawrence D.
Daniel, Jonathan
Larsen, Brandon T.
Crawford, Russell
Bishop, Maria C.
Source
Case Reports in Oncological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-30
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Giant-cell tumor of the bone (GCTB) is a rare neoplasm that affects young adults.
The tumor is generally benign but sometimes can be locally aggressive.
There are no standardized approaches to the treatment of GCTB.
Recently, the RANKL inhibitor denosumab has shown activity in this tumor type.
We present the case of a young female who presented with locally advanced disease and was successfully managed with the neoadjuvant use of denosumab allowing for surgical resection of the tumor that was previously deemed unresectable.
Following surgery, the patient is being managed with continued use of denosumab as ‘maintenance,’ and she continues to be free of disease.
Our case highlights a novel approach for the management of locally advanced and aggressive giant cell tumor of the bone.
American Psychological Association (APA)
Agarwal, Amit& Larsen, Brandon T.& Buadu, Lawrence D.& Dunn, Jack& Crawford, Russell& Daniel, Jonathan…[et al.]. 2013. Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone : A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-476307
Modern Language Association (MLA)
Agarwal, Amit…[et al.]. Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone : A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-476307
American Medical Association (AMA)
Agarwal, Amit& Larsen, Brandon T.& Buadu, Lawrence D.& Dunn, Jack& Crawford, Russell& Daniel, Jonathan…[et al.]. Denosumab Chemotherapy for Recurrent Giant-Cell Tumor of Bone : A Case Report of Neoadjuvant Use Enabling Complete Surgical Resection. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-476307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476307