Modelling Human Channelopathies Using Induced Pluripotent Stem Cells : A Comprehensive Review
Joint Authors
Seufferlein, Thomas
Müller, Martin
Illing, Anett
Homann, Jörg
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
The generation of induced pluripotent stem cells (iPS cells) has pioneered the field of regenerative medicine and developmental biology.
They can be generated by overexpression of a defined set of transcription factors in somatic cells derived from easily accessible tissues such as skin or plucked hair or even human urine.
In case of applying this tool to patients who are classified into a disease group, it enables the generation of a disease- and patient-specific research platform.
iPS cells have proven a significant tool to elucidate pathophysiological mechanisms in various diseases such as diabetes, blood disorders, defined neurological disorders, and genetic liver disease.
One of the first successfully modelled human diseases was long QT syndrome, an inherited cardiac channelopathy which causes potentially fatal cardiac arrhythmia.
This review summarizes the efforts of reprogramming various types of long QT syndrome and discusses the potential underlying mechanisms and their application.
American Psychological Association (APA)
Müller, Martin& Seufferlein, Thomas& Illing, Anett& Homann, Jörg. 2013. Modelling Human Channelopathies Using Induced Pluripotent Stem Cells : A Comprehensive Review. Stem Cells International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476321
Modern Language Association (MLA)
Müller, Martin…[et al.]. Modelling Human Channelopathies Using Induced Pluripotent Stem Cells : A Comprehensive Review. Stem Cells International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476321
American Medical Association (AMA)
Müller, Martin& Seufferlein, Thomas& Illing, Anett& Homann, Jörg. Modelling Human Channelopathies Using Induced Pluripotent Stem Cells : A Comprehensive Review. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476321
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476321