Primary Hairy Cell LeukemiaLymphoma of the Breast : A Case Report and Review of the Literature
Joint Authors
Shariftabrizi, Ahmad
Mukand-Cerro, Ian
Pilichowska, Monika
Miller, Kenneth
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Hairy cell leukemia/lymphoma (HCL) is a rare B-cell neoplasm primarily involving spleen, bone marrow, and blood.
However, other sites of primary involvement do occur and can present a diagnostic and therapeutic challenge.
We present an unusual case of HCL involving predominantly the breast that was diagnosed as an incidental finding during an elective reduction mammoplasty in an otherwise healthy asymptomatic woman.
Bone marrow performed for staging revealed limited involvement by HCL.
Notably, there was no splenomegaly and/or involvement of other extramedullary sites.
The peripheral blood revealed minimal involvement detected by flow cytometry.
Extensive immunohistochemical studies supported by positive BRAF V600E mutational status confirmed the diagnosis of HCL.
The patient remains asymptomatic without treatment one year following the diagnosis.
This is the first case of a well-documented HCL presenting primarily in the breast in an asymptomatic patient.
We review the literature on extramedullary, extrasplenic involvement by HCL and discuss the diagnostic challenges as well as the utility of immunohistochemistry and molecular studies in the diagnosis of atypical presentations of HCL.
American Psychological Association (APA)
Pilichowska, Monika& Shariftabrizi, Ahmad& Mukand-Cerro, Ian& Miller, Kenneth. 2014. Primary Hairy Cell LeukemiaLymphoma of the Breast : A Case Report and Review of the Literature. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476357
Modern Language Association (MLA)
Pilichowska, Monika…[et al.]. Primary Hairy Cell LeukemiaLymphoma of the Breast : A Case Report and Review of the Literature. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-476357
American Medical Association (AMA)
Pilichowska, Monika& Shariftabrizi, Ahmad& Mukand-Cerro, Ian& Miller, Kenneth. Primary Hairy Cell LeukemiaLymphoma of the Breast : A Case Report and Review of the Literature. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476357
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476357