Possible Association of IL-4 VNTR Polymorphism with Susceptibility to Preeclampsia
Joint Authors
Mohammadoo-khorasani, Milad
Salimi, Saeedeh
Yaghmaei, Minoo
Moossavi, Maryam
Mokhtari, Mojgan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Preeclampsia (PE) is a pregnancy-specific disorder that results in maternal mortality and morbidity.
Growing evidence indicated that cytokines are involved in the pathogenesis of PE and interleukin-4 VNTR polymorphism could be implicated in altering the PE risk.
The aim of this study was to evaluate the possible association between IL-4 VNTR polymorphism and susceptibility to PE in Iranian population for the first time.
Genetic polymorphism was evaluated in 192 PE and 186 healthy control women by polymerase chain reaction method.
We found that the VNTR polymorphism of IL-4 gene has significantly increased the risk of preeclampsia (RP2/RP1 versus RP1/RP1, OR, 2.8 [95% CI, 1.7 to 8.8]; P=0.0001 and RP2/RP2 versus RP1/RP1; P=0.002).
The results showed that carriage of IL-4 VNTR RP2 allele has positive association with preeclampsia susceptibility.
American Psychological Association (APA)
Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Yaghmaei, Minoo& Mokhtari, Mojgan& Moossavi, Maryam. 2014. Possible Association of IL-4 VNTR Polymorphism with Susceptibility to Preeclampsia. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476359
Modern Language Association (MLA)
Salimi, Saeedeh…[et al.]. Possible Association of IL-4 VNTR Polymorphism with Susceptibility to Preeclampsia. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-476359
American Medical Association (AMA)
Salimi, Saeedeh& Mohammadoo-khorasani, Milad& Yaghmaei, Minoo& Mokhtari, Mojgan& Moossavi, Maryam. Possible Association of IL-4 VNTR Polymorphism with Susceptibility to Preeclampsia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476359
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476359