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Autoimmunity in Amyotrophic Lateral Sclerosis : Past and Present
Joint Authors
Gonzalez, Laura Elisabeth
Uchitel, Osvaldo Daniel
Pagani, Mario Rafael
Source
Neurology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting particularly motor neurons for which no cure or effective treatment is available.
Although the cause of ALS remains unknown, accumulative evidence suggests an autoimmune mechanism of pathogenesis.
In this paper, we will summarize the current research related to autoimmunity in the sporadic form of ALS and discuss the potential underlying pathogenic mechanisms and perspectives.
Presented data supports the view that humoral immune responses against motor nerve terminals can initiate a series of physiological changes leading to alteration of calcium homeostasis.
In turn, loss of calcium homeostasis may induce neuronal death through apoptotic signaling pathways.
Additional approaches identifying specific molecular features of this hypothesis are required, which will hopefully allow us to develop techniques of early diagnosis and effective therapies.
American Psychological Association (APA)
Pagani, Mario Rafael& Gonzalez, Laura Elisabeth& Uchitel, Osvaldo Daniel. 2011. Autoimmunity in Amyotrophic Lateral Sclerosis : Past and Present. Neurology Research International،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-476363
Modern Language Association (MLA)
Pagani, Mario Rafael…[et al.]. Autoimmunity in Amyotrophic Lateral Sclerosis : Past and Present. Neurology Research International No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-476363
American Medical Association (AMA)
Pagani, Mario Rafael& Gonzalez, Laura Elisabeth& Uchitel, Osvaldo Daniel. Autoimmunity in Amyotrophic Lateral Sclerosis : Past and Present. Neurology Research International. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-476363
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476363