![](/images/graphics-bg.png)
Cytogenetics and Molecular Genetics of Myxoid Soft-Tissue Sarcomas
Joint Authors
Naito, Masatoshi
Nishio, Jun
Nabeshima, Kazuki
Iwasaki, Hiroshi
Source
Genetics Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-28
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Myxoid soft-tissue sarcomas represent a heterogeneous group of mesenchymal tumors characterized by a predominantly myxoid matrix, including myxoid liposarcoma (MLS), low-grade fibromyxoid sarcoma (LGFMS), extraskeletal myxoid chondrosarcoma (EMC), myxofibrosarcoma, myxoinflammatory fibroblastic sarcoma (MIFS), and myxoid dermatofibrosarcoma protuberans (DFSP).
Cytogenetic and molecular genetic analyses have shown that many of these sarcomas are characterized by recurrent chromosomal translocations resulting in highly specific fusion genes (e.g., FUS-DDIT3 in MLS, FUS-CREB3L2 in LGFMS, EWSR1-NR4A3 in EMC, and COL1A1-PDGFB in myxoid DFSP).
Moreover, recent molecular analysis has demonstrated a translocation t(1; 10)(p22; q24) resulting in transcriptional upregulation of FGF8 and NPM3 in MIFS.
Most recently, the presence of TGFBR3 and MGEA5 rearrangements has been identified in a subset of MIFS.
These genetic alterations can be utilized as an adjunct in diagnostically challenging cases.
In contrast, most myxofibrosarcomas have complex karyotypes lacking specific genetic alterations.
This paper focuses on the cytogenetic and molecular genetic findings of myxoid soft-tissue sarcomas as well as their clinicopathological characteristics.
American Psychological Association (APA)
Nishio, Jun& Iwasaki, Hiroshi& Nabeshima, Kazuki& Naito, Masatoshi. 2011. Cytogenetics and Molecular Genetics of Myxoid Soft-Tissue Sarcomas. Genetics Research International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-476368
Modern Language Association (MLA)
Nishio, Jun…[et al.]. Cytogenetics and Molecular Genetics of Myxoid Soft-Tissue Sarcomas. Genetics Research International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-476368
American Medical Association (AMA)
Nishio, Jun& Iwasaki, Hiroshi& Nabeshima, Kazuki& Naito, Masatoshi. Cytogenetics and Molecular Genetics of Myxoid Soft-Tissue Sarcomas. Genetics Research International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-476368
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476368