Effects of Quercetin on CYP450 and Cytokines in Aroclor 1254 Injured Endometrial Cells of the Pregnant Rats
Joint Authors
Qin, Jianhua
Ma, Yuzhong
Lu, Liqin
Sun, Liyun
Zhong, Xiuhui
Xu, Lina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Polychlorinated biphenyls (PCBs) are widespread persistent residual environmental pollutants, which affect seriously the growth and reproductive alterations in humans and animals.
Aroclor 1254 is a commercial mixture of PCBs.
Quercetin is a flavonoid, which acts on estrogen receptors and causes the development of estrogen-related diseases.
In this paper, the primary cultured endometrial cells in the pregnant rats were isolated and Aroclor 1254 was used to induce the injured endometrial cells model.
The cells were treated with gradient quercetin, the viability of the endometrial cells, the expressions of CYP450, the contents of TNF-α, IL-6, estradiol (E2), and progesterone (P4) were measured.
It showed that the viability of the cultured endometrial cells, the expression of CYP1A1 and CYP2B1, and the contents of TNF-α, E2, and IL-6 in the injured endometrial cells increased with the treatment of quercetin.
It shows that quercetin has protective effect on the injured endometrial cells in the pregnant rats, this provide a basis on herbal medicine protection for animal reproductive diseases caused by environmental endocrine disruptors.
American Psychological Association (APA)
Xu, Lina& Sun, Liyun& Lu, Liqin& Zhong, Xiuhui& Ma, Yuzhong& Qin, Jianhua. 2014. Effects of Quercetin on CYP450 and Cytokines in Aroclor 1254 Injured Endometrial Cells of the Pregnant Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476401
Modern Language Association (MLA)
Xu, Lina…[et al.]. Effects of Quercetin on CYP450 and Cytokines in Aroclor 1254 Injured Endometrial Cells of the Pregnant Rats. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-476401
American Medical Association (AMA)
Xu, Lina& Sun, Liyun& Lu, Liqin& Zhong, Xiuhui& Ma, Yuzhong& Qin, Jianhua. Effects of Quercetin on CYP450 and Cytokines in Aroclor 1254 Injured Endometrial Cells of the Pregnant Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476401
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476401