Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases : Towards Future Therapeutic Application
Joint Authors
Farfara, Dorit
Trudler, Dorit
Frenkel, Dan
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Toll-like receptors (TLRs) are known to be expressed by innate immune response cells and to play a critical role in their activation against foreign pathogens.
It was recently suggested that TLRs have an important role in the crosstalk between neurons and glial cells in the central nervous system (CNS).
TLR signaling was reported to be associated with a yin-yang effect in the CNS.
While TLR signaling was linked to neurogenesis, it was also found to be involved in the pathogenesis of neurodegenerative diseases.
This paper will focus on TLR signaling in glial cells in neurodegenerative diseases such as Alzheimer's disease, prion diseases, amyotrophic lateral sclerosis, and Parkinson's disease.
Understanding the pattern of TLR signaling in the glial cells may lead to the identification of new targets for therapeutic application.
American Psychological Association (APA)
Trudler, Dorit& Farfara, Dorit& Frenkel, Dan. 2010. Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases : Towards Future Therapeutic Application. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-476445
Modern Language Association (MLA)
Trudler, Dorit…[et al.]. Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases : Towards Future Therapeutic Application. Mediators of Inflammation No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-476445
American Medical Association (AMA)
Trudler, Dorit& Farfara, Dorit& Frenkel, Dan. Toll-Like Receptors Expression and Signaling in Glia Cells in Neuro-Amyloidogenic Diseases : Towards Future Therapeutic Application. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-476445
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476445