Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand 18F-FPCIT
Joint Authors
Bjelke, David
Robeson, William
Eidelberg, David
Dhawan, Vijay
Chaly, Thomas
Ma, Yilong
Margouleff, Claude
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-29
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Our previous dosimetry studies have demonstrated that for dopaminergic radiotracers, 18F-FDOPA and 18F-FPCIT, the urinary bladder is the critical organ.
As these tracers accumulate in the basal ganglia (BG) with high affinity and long residence times, radiation dose to the BG may become significant, especially in normal control subjects.
We have performed dynamic PET measurements using 18F-FPCIT in 16 normal adult subjects to determine if in fact the BG, although not a whole organ, but a well-defined substructure, receives the highest dose.
Regions of interest were drawn over left and right BG structures.
Resultant time-activity curves were generated and used to determine residence times for dosimetry calculations.
S-factors were computed using the MIRDOSE3 nodule model for each caudate and putamen.
For 18F-FPCIT, BG dose ranged from 0.029 to 0.069 mGy/MBq.
In half of all subjects, BG dose exceeded 85% of the published critical organ (bladder) dose, and in three of those, the BG dose exceeded that for the bladder.
The BG can become the dose-limiting organ in studies using dopamine transporter ligands.
For some normal subjects studied with F-18 or long half-life radionuclide, the BG may exceed bladder dose and become the critical structure.
American Psychological Association (APA)
Robeson, William& Dhawan, Vijay& Ma, Yilong& Bjelke, David& Margouleff, Claude& Chaly, Thomas…[et al.]. 2014. Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand 18F-FPCIT. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476457
Modern Language Association (MLA)
Robeson, William…[et al.]. Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand 18F-FPCIT. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-476457
American Medical Association (AMA)
Robeson, William& Dhawan, Vijay& Ma, Yilong& Bjelke, David& Margouleff, Claude& Chaly, Thomas…[et al.]. Radiation Absorbed Dose to the Basal Ganglia from Dopamine Transporter Radioligand 18F-FPCIT. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-476457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476457