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The Golgi in Cell Migration : Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis
Joint Authors
Millarte, Valentina
Farhan, Hesso
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Migration and invasion are fundamental features of metastatic cancer cells.
The Golgi apparatus, an organelle involved in posttranslational modification and sorting of proteins, is widely accepted to regulate directional cell migration.
In addition, mounting evidence suggests that the Golgi is a hub for different signaling pathways.
In this paper we will give an overview on how polarized secretion and microtubule nucleation at the Golgi regulate directional cell migration.
We will review different signaling pathways that signal to and from the Golgi.
Finally, we will discuss how these signaling pathways regulate the role of the Golgi in cell migration and invasion.
We propose that by identifying regulators of the Golgi, we might be able to uncover unappreciated modulators of cell migration.
Uncovering the regulatory network that orchestrates cell migration is of fundamental importance for the development of new therapeutic strategies against cancer cell metastasis.
American Psychological Association (APA)
Millarte, Valentina& Farhan, Hesso. 2012. The Golgi in Cell Migration : Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476483
Modern Language Association (MLA)
Millarte, Valentina& Farhan, Hesso. The Golgi in Cell Migration : Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis. The Scientific World Journal No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-476483
American Medical Association (AMA)
Millarte, Valentina& Farhan, Hesso. The Golgi in Cell Migration : Regulation by Signal Transduction and Its Implications for Cancer Cell Metastasis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476483
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476483