Development and Maturation of the Immune System in Preterm Neonates : Results from a Whole Genome Expression Study
Joint Authors
Pietrzyk, Jacek Józef
Durlak, Wojciech
Zasada, Magdalena
Kwinta, Przemko
Bik-Multanowski, Mirosław
Madetko-Talowska, Anna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To expand the knowledge about the consecutive expression of genes involved in the immune system development in preterm neonates and to verify if the environment changes the gene expression after birth we conducted a prospective study that included three cohorts: (A) extremely (gestational age (GA): 23–26 weeks; n=41), (B) very (GA: 27–29 weeks; n=39), and (C) moderately preterm infants (GA: 30–32 weeks; n=33).
Blood samples were drawn from the study participants on the 5th and 28th day of life (DOL).
The mRNA samples were evaluated for gene expression with the use of GeneChip Human Gene 1.0ST microarrays.
Differential expression analysis revealed small subsets of genes that presented positive or negative monotone trends in both the 5th (138 genes) and 28th DOL (308 genes) in the three subgroups of patients.
Based on pathway enrichment analysis, we found that most of the pathways that revealed a positive monotone trend were involved in host immunity.
The most significantly GA dependent pathways were T-cell receptor signaling pathway and intestinal immune network for IgA production.
Overall 4431 genes were differentially expressed between the 5th and 28th DOL.
Despite differences in gestational age, patients with the same postconceptional age have a very similar expression of genes.
American Psychological Association (APA)
Zasada, Magdalena& Kwinta, Przemko& Durlak, Wojciech& Bik-Multanowski, Mirosław& Madetko-Talowska, Anna& Pietrzyk, Jacek Józef. 2014. Development and Maturation of the Immune System in Preterm Neonates : Results from a Whole Genome Expression Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-476487
Modern Language Association (MLA)
Zasada, Magdalena…[et al.]. Development and Maturation of the Immune System in Preterm Neonates : Results from a Whole Genome Expression Study. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-476487
American Medical Association (AMA)
Zasada, Magdalena& Kwinta, Przemko& Durlak, Wojciech& Bik-Multanowski, Mirosław& Madetko-Talowska, Anna& Pietrzyk, Jacek Józef. Development and Maturation of the Immune System in Preterm Neonates : Results from a Whole Genome Expression Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-476487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476487