Lenalidomide in Diffuse Large B-Cell Lymphomas
Joint Authors
Vitolo, Umberto
Chiappella, Annalisa
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Diffuse Large B-cell Lymphomas (DLBCL) are the most frequent Non-Hodgkin Lymphomas (NHL).
The addition of Rituximab to the standard chemotherapy CHOP improved the outcome in this patients, but so far 40% of patients experienced relapse or progressive disease.
Lenalidomide, an immunomodulatory agent, had direct tumoricidal and antiangiogenetic actions on tumor cells and was able to modulate tumor-cell microenvironment, with the restoration of impaired T-cell activity and the formation of immuno-synapsis.
Based on these actions, lenalidomide represented an active drug on aggressive relapsed NHL.
In this review, the most relevant clinical trials for the use of lenalidomide in DLBCL were reported.
Monotherapy with lenalidomide showed an activity in term of overall response rate, with acceptable hematological and extrahematological toxicities in relapsed/refractory aggressive NHL.
The role of lenalidomide as salvage therapy in both cell of origin patterns in DLBCL (germinal center B-cell/activated B-cell) was reported in preliminary data.
Preliminary data regarding the role of lenalidomide in addition to chemoimmunotherapy (R-CHOP) in first line clinical trials were discussed; data of safety, feasibility and efficacy were promising.
American Psychological Association (APA)
Chiappella, Annalisa& Vitolo, Umberto. 2012. Lenalidomide in Diffuse Large B-Cell Lymphomas. Advances in Hematology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476490
Modern Language Association (MLA)
Chiappella, Annalisa& Vitolo, Umberto. Lenalidomide in Diffuse Large B-Cell Lymphomas. Advances in Hematology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-476490
American Medical Association (AMA)
Chiappella, Annalisa& Vitolo, Umberto. Lenalidomide in Diffuse Large B-Cell Lymphomas. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476490