Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ
Joint Authors
Bassaganya-Riera, Josep
Misyak, Sarah A.
Hontecillas, Raquel
Carter, Ashlee B.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-04-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Mounting evidence suggests that the risk of developing colorectal cancer (CRC) is dramatically increased for patients with chronic inflammatory diseases.
For instance, patients with Crohn's Disease (CD) or Ulcerative Colitis (UC) have a 12–20% increased risk for developing CRC.
Preventive strategies utilizing nontoxic natural compounds that modulate immune responses could be successful in the suppression of inflammation-driven colorectal cancer in high-risk groups.
The increase of peroxisome proliferator-activated receptor-γ (PPAR-γ) expression and its transcriptional activity has been identified as a target for anti-inflammatory efforts, and the suppression of inflammation-driven colon cancer.
PPARγ down-modulates inflammation and elicits antiproliferative and proapoptotic actions in epithelial cells.
All of which may decrease the risk for inflammation-induced CRC.
This review will focus on the use of orally active, naturally occurring chemopreventive approaches against inflammation-induced CRC that target PPARγ and therefore down-modulate inflammation.
American Psychological Association (APA)
Carter, Ashlee B.& Misyak, Sarah A.& Hontecillas, Raquel& Bassaganya-Riera, Josep. 2009. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ. PPAR Research،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-476492
Modern Language Association (MLA)
Carter, Ashlee B.…[et al.]. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ. PPAR Research No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-476492
American Medical Association (AMA)
Carter, Ashlee B.& Misyak, Sarah A.& Hontecillas, Raquel& Bassaganya-Riera, Josep. Dietary Modulation of Inflammation-Induced Colorectal Cancer through PPARγ. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-476492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476492