Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus
Joint Authors
Ishigaki, Yasushi
Kudo, Hirohito
Emi, Mitsuru
Ishii, Miho
Hinokio, Yoshinori
Tsunoda, Uiko
Oka, Yoshitomo
Yamada, Tetsuya
Katagiri, Hideki
Sato, Hidenori
Source
Experimental Diabetes Research
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
A small portion of Type 2 diabetes mellitus (T2DM) is familial, but the majority occurs as sporadic disease.
Although causative genes are found in some rare forms, the genetic basis for sporadic T2DM is largely unknown.
We searched for a copy number abnormality in 100 early-onset Japanese T2DM patients (onset age <35 years) by whole-genome screening with a copy number variation BeadChip.
Within the 1.3-Mb subtelomeric region on chromosome 4p16.3, we found copy number losses in early-onset T2DM (13 of 100 T2DM versus one of 100 controls).
This region surrounds a genome gap, which is rich in multiple low copy repeats.
Subsequent region-targeted high-density custom-made oligonucleotide microarray experiments verified the copy number losses and delineated structural changes in the 1.3-Mb region.
The results suggested that copy number losses of the genes in the deleted region around the genome gap in 4p16.3 may play significant roles in the etiology of T2DM.
American Psychological Association (APA)
Kudo, Hirohito& Emi, Mitsuru& Ishigaki, Yasushi& Tsunoda, Uiko& Hinokio, Yoshinori& Ishii, Miho…[et al.]. 2011. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Experimental Diabetes Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-476503
Modern Language Association (MLA)
Kudo, Hirohito…[et al.]. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Experimental Diabetes Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-476503
American Medical Association (AMA)
Kudo, Hirohito& Emi, Mitsuru& Ishigaki, Yasushi& Tsunoda, Uiko& Hinokio, Yoshinori& Ishii, Miho…[et al.]. Frequent Loss of Genome Gap Region in 4p16.3 Subtelomere in Early-Onset Type 2 Diabetes Mellitus. Experimental Diabetes Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-476503
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476503