The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain
Joint Authors
Gürpınar, Tuğba
Barut, Turgay
Tarakçı, Figen
Ekerbiçer, Nuran
Tuglu, M. Ibrahim
Uysal, Nazan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Oxidative stress plays an important role in the development of complications in diabetes mellitus.
Antioxidant therapy has been thought to decrease oxidative stress.
The objective of the present study was to explore the effects of melatonin (MLT) on oxidative stress in diabetic rat eye and brain tissue by using immunohistochemical methods.
Diabetes was induced by streptozotocin, (STZ, 55 mg/kg/i.p) in adult rats.
MLT was given 10 mg/kg/i.p once a day for 2 weeks beginning from the sixth week.
Six weeks later, rats were divided into three groups: control (CR), STZ-induced diabetic (STZ), and STZ-induced diabetic group received melatonin (STZ+MLT).
Although no significant difference was observed with respect to antioxidant status, NOS activity tended to be higher in the untreated diabetic rats than in the treated rats.
It was observed that MLT treatment improved the histopathological changes including apoptosis and oxidative stress in brain and eye in diabetic rat.
American Psychological Association (APA)
Gürpınar, Tuğba& Ekerbiçer, Nuran& Uysal, Nazan& Barut, Turgay& Tarakçı, Figen& Tuglu, M. Ibrahim. 2012. The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476508
Modern Language Association (MLA)
Gürpınar, Tuğba…[et al.]. The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain. The Scientific World Journal No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-476508
American Medical Association (AMA)
Gürpınar, Tuğba& Ekerbiçer, Nuran& Uysal, Nazan& Barut, Turgay& Tarakçı, Figen& Tuglu, M. Ibrahim. The Effects of the Melatonin Treatment on the Oxidative Stress and Apoptosis in Diabetic Eye and Brain. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-476508
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476508