Autophagy in Alcohol-Induced Multiorgan Injury : Mechanisms and Potential Therapeutic Targets
Joint Authors
Ni, Hong-Min
Ding, Wen-Xing
Wang, Shaogui
Huang, Heqing
Li, Yuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Autophagy is a genetically programmed, evolutionarily conserved intracellular degradation pathway involved in the trafficking of long-lived proteins and cellular organelles to the lysosome for degradation to maintain cellular homeostasis.
Alcohol consumption leads to injury in various tissues and organs including liver, pancreas, heart, brain, and muscle.
Emerging evidence suggests that autophagy is involved in alcohol-induced tissue injury.
Autophagy serves as a cellular protective mechanism against alcohol-induced tissue injury in most tissues but could be detrimental in heart and muscle.
This review summarizes current knowledge about the role of autophagy in alcohol-induced injury in different tissues/organs and its potential molecular mechanisms as well as possible therapeutic targets based on modulation of autophagy.
American Psychological Association (APA)
Li, Yuan& Wang, Shaogui& Ni, Hong-Min& Huang, Heqing& Ding, Wen-Xing. 2014. Autophagy in Alcohol-Induced Multiorgan Injury : Mechanisms and Potential Therapeutic Targets. BioMed Research International،Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-476509
Modern Language Association (MLA)
Li, Yuan…[et al.]. Autophagy in Alcohol-Induced Multiorgan Injury : Mechanisms and Potential Therapeutic Targets. BioMed Research International No. 2014 (2014), pp.1-20.
https://search.emarefa.net/detail/BIM-476509
American Medical Association (AMA)
Li, Yuan& Wang, Shaogui& Ni, Hong-Min& Huang, Heqing& Ding, Wen-Xing. Autophagy in Alcohol-Induced Multiorgan Injury : Mechanisms and Potential Therapeutic Targets. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-20.
https://search.emarefa.net/detail/BIM-476509
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476509