Modulation of Vasomotive Activity in Rabbit External Ophthalmic Artery by Neuropeptides
Joint Authors
Delgado, Esmeralda Sofia Costa
Silva-Carvalho, Luís Filipe
Marques-Neves, Carlos
Rocha, Maria Isabel Sousa
Sales-Luís, José Paulo Pacheco
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To investigate the vasomotive activity upon the external ophthalmic artery of vasointestinal peptide (VIP) and neuropeptide Y (NPY) using a previously developed model.
Methods.
Isolated rabbit eyes (n=12) were perfused in situ with tyrode through the external ophthalmic artery.
Effects of intra-arterial injections of NPY 200 μg/ml (Group A; n=6) and VIP 200 μg/ml (Group B; n=6) on the recorded pressure were obtained.
For statistical analysis, Student's paired t-test and Fast Fourier Transform were used.
Results.
Spontaneous oscillations were observed before any drug administration in the 12 rabbit models.
NPY produced an increase in total vascular resistance and a higher frequency and amplitude of oscillations, while VIP evoked the opposite effects.
Conclusions.
This study provides evidence of vasomotion in basal conditions in rabbit external ophthalmic artery.
Concerning drug effects, NPY increased arterial resistance and enhanced vasomotion while VIP produced opposite effects which demonstrates their profound influence in arterial vasomotion.
American Psychological Association (APA)
Delgado, Esmeralda Sofia Costa& Marques-Neves, Carlos& Rocha, Maria Isabel Sousa& Sales-Luís, José Paulo Pacheco& Silva-Carvalho, Luís Filipe. 2012. Modulation of Vasomotive Activity in Rabbit External Ophthalmic Artery by Neuropeptides. Journal of Ophthalmology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476517
Modern Language Association (MLA)
Delgado, Esmeralda Sofia Costa…[et al.]. Modulation of Vasomotive Activity in Rabbit External Ophthalmic Artery by Neuropeptides. Journal of Ophthalmology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-476517
American Medical Association (AMA)
Delgado, Esmeralda Sofia Costa& Marques-Neves, Carlos& Rocha, Maria Isabel Sousa& Sales-Luís, José Paulo Pacheco& Silva-Carvalho, Luís Filipe. Modulation of Vasomotive Activity in Rabbit External Ophthalmic Artery by Neuropeptides. Journal of Ophthalmology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476517