Anti-CCP Antibodies Are Not Associated with Familial Mediterranean Fever in Childhood

Abstract EN

Objective.

Anticyclic citrullinated peptide antibodies (anti-CCP) testing is useful in the diagnosis of rheumatoid arthritis (RA) with high specificity.

Arthritis is a very common clinical manifestation in children with familial Mediterranean fever (FMF).

The aim of the study was to show the presence of anti-CCP antibodies in child individuals diagnosed with FMF.

Material and Methods.

The study groups comprised one hundred and twenty-six patients (126) diagnosed with FMF (female/male (n): 66/60) and 50 healthy controls (female/male (n): 25/25).

Clinical and laboratory assessments of the FMF patients were performed during attack-free periods.

Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), fibrinogen, and anti-CCP antibody levels were measured.

Results.

Anti-CCP was negative in healthy controls and also in all FMF patients.

There was not a significant difference in anti-CCP between the patient and the control groups.

Our study has shown that anti-CCP was correlated moderately with age (rs=0.271; P=0.0020), duration of illness (rs=0.331; P<0.0001), and colchicine therapy (rs=0.259; P=0.004).

Conclusion.

Our data show that anti-CCP antibodies are not associated with FMF.

Anti-CCP does not have a priority for identifying FMF arthritis from the other inflammatory arthritis.