Synthesis and Characterisation of First Generation Luminescent Lanthanide Complexes Suitable for Being Adapted for Uptake via the Mannose Receptor
Joint Authors
Du, Zhangli
Brooks, Robert
Brooks, Douglas
Plush, Sally
Borlace, Glenn
Source
Journal of Inorganic Chemistry
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
With the aim of directing lanthanide complex uptake via the mannose receptor, a first generation of luminescent lanthanide complexes has been developed with an α-D-mannose targeting motif.
Four complexes were produced to investigate photophysical properties and determine the effect of the coordinated mannose residue on emission intensity.
The free hydroxyls of the α-D-mannose residue quenched lanthanide phosphorescence due to their close proximity, though they did not bind the lanthanide centre as observed by q-values ≈1.0 for all complexes between pH 3 and 10.
Fluorescent emission was found to vary significantly with pH, though phosphorescent emission was relatively insensitive to pH.
This lack of pH sensitivity has the potential to provide stable emission for the visualisation of the endosome-lysosome system where acidic pH is often encountered.
American Psychological Association (APA)
Brooks, Robert& Du, Zhangli& Borlace, Glenn& Brooks, Douglas& Plush, Sally. 2013. Synthesis and Characterisation of First Generation Luminescent Lanthanide Complexes Suitable for Being Adapted for Uptake via the Mannose Receptor. Journal of Inorganic Chemistry،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476522
Modern Language Association (MLA)
Brooks, Robert…[et al.]. Synthesis and Characterisation of First Generation Luminescent Lanthanide Complexes Suitable for Being Adapted for Uptake via the Mannose Receptor. Journal of Inorganic Chemistry No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-476522
American Medical Association (AMA)
Brooks, Robert& Du, Zhangli& Borlace, Glenn& Brooks, Douglas& Plush, Sally. Synthesis and Characterisation of First Generation Luminescent Lanthanide Complexes Suitable for Being Adapted for Uptake via the Mannose Receptor. Journal of Inorganic Chemistry. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-476522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476522