Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans
Joint Authors
Halimi, Jean-Michel
Andres, Christian
Respaud, Renaud
Hulot, Jean-Sébastien
Benz-de Bretagne, Isabelle
Le Guellec, Chantal
Caille, Agnès
Vourc'h, Patrick
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MRP2 encoded by ABCC2 gene is involved in the secretion of numerous drugs and endogenous substrates.
Patients with Dubin-Johnson syndrome due to mutation in ABCC2 gene have elevated urinary coproporphyrin ratio (UCP I/(I + III)).
Here we investigated whether this ratio could serve as a biomarker of MRP2 function.
Phenotype-genotype relationships were studied in 74 healthy subjects by measuring individual UCP I/(I + III) ratio obtained on 24-hour urine and by analyzing five common SNPs in ABCC2 gene.
The UCP I/(I + III) ratio varied from 14.7% to 46.0% in our population.
Subjects with 3972TT genotype had a higher ratio (P=.04) than those carrying the C allele.
This higher UCP I/(I + III) ratio was correlated with a higher level of isomer I excretion.
This study provides a proof of concept that UCP I/(I + III) ratio can be used as a biomarker of MRP2 function in clinical studies as it provides quantitative information about the in vivo activity of MRP2 in a given patient.
American Psychological Association (APA)
Benz-de Bretagne, Isabelle& Respaud, Renaud& Vourc'h, Patrick& Halimi, Jean-Michel& Caille, Agnès& Hulot, Jean-Sébastien…[et al.]. 2011. Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476533
Modern Language Association (MLA)
Benz-de Bretagne, Isabelle…[et al.]. Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-476533
American Medical Association (AMA)
Benz-de Bretagne, Isabelle& Respaud, Renaud& Vourc'h, Patrick& Halimi, Jean-Michel& Caille, Agnès& Hulot, Jean-Sébastien…[et al.]. Urinary Elimination of Coproporphyrins Is Dependent on ABCC2 Polymorphisms and Represents a Potential Biomarker of MRP2 Activity in Humans. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476533
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476533