PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast
Joint Authors
Ohsumi, Yoshinori
Obara, Keisuke
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Eukaryotic cells can massively transport their own cytoplasmic contents into a lytic compartment, the vacuole/lysosome, for recycling through a conserved system called autophagy.
The key process in autophagy is the sequestration of cytoplasmic contents within a double-membrane structure, the autophagosome.
Autophagosome formation requires the elaborate cooperation of Atg (autophagy-related) proteins and lipid molecules.
Phosphorylation of phosphatidylinositol (PtdIns) by a PtdIns 3-kinase, Vps34, is a key step in coordinating Atg proteins and lipid molecules.
Vps34 forms two distinct protein complexes, only one of which is involved in generating autophagic membranes.
Upon induction of autophagy, PtdIns(3)P, the enzymatic product of PtdIns 3-kinase, is massively transported into the lumen of the vacuole via autophagy.
PtdIns(3)P is enriched on the inner membrane of the autophagosome.
PtdIns(3)P recruits the Atg18−Atg2 complex and presumably other Atg proteins to autophagic membranes, thereby coordinating lipid molecules and Atg proteins.
American Psychological Association (APA)
Obara, Keisuke& Ohsumi, Yoshinori. 2011. PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. Journal of Lipids،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476534
Modern Language Association (MLA)
Obara, Keisuke& Ohsumi, Yoshinori. PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. Journal of Lipids No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-476534
American Medical Association (AMA)
Obara, Keisuke& Ohsumi, Yoshinori. PtdIns 3-Kinase Orchestrates Autophagosome Formation in Yeast. Journal of Lipids. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476534
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476534