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Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines
Joint Authors
Soleimani, Masoud
Shabani, Fahmideh
Kaviani, Saeid
Teimouri, Mohammad Bagher
Mehrani, Khayroallah
Ghammamy, Shahriar
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-26
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
(6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione) abbreviated as CDP was synthesized and characterized.
Ti(IV), Zn(II), Fe(III), and Pd(II) metal complexes of this ligand are prepared by the reaction of salts of Ti(IV), Zn(II), Fe(III), and Pd(II) with CDP in acetonitrile.
Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR, 13C NMR, and UV-Visible spectroscopy.
All complexes were characterized by several techniques using elemental analysis (C, H, N), FT-IR, electronic spectra, and molar conductance measurements.
The elemental analysis data suggest the stoichiometry to be 1:1 [M:L] ratio formation.
The molar conductance measurements reveal the presence of 1:1 electrolytic nature complexes.
These new complexes showed excellent antitumor activity against two kinds of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.
American Psychological Association (APA)
Shabani, Fahmideh& Ghammamy, Shahriar& Mehrani, Khayroallah& Teimouri, Mohammad Bagher& Soleimani, Masoud& Kaviani, Saeid. 2009. Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines. Bioinorganic Chemistry and Applications،Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-476547
Modern Language Association (MLA)
Shabani, Fahmideh…[et al.]. Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines. Bioinorganic Chemistry and Applications No. 2008 (2008), pp.1-5.
https://search.emarefa.net/detail/BIM-476547
American Medical Association (AMA)
Shabani, Fahmideh& Ghammamy, Shahriar& Mehrani, Khayroallah& Teimouri, Mohammad Bagher& Soleimani, Masoud& Kaviani, Saeid. Antitumor Activity of 6-(cyclohexylamino)-1,3-dimethyl-5(2-pyridyl)furo[2,3-d]pyrimidine-2,4(1H,3H)-dione and Its Ti(IV), Zn(II), Fe(III), and Pd(II) Complexes on K562 and Jurkat Cell Lines. Bioinorganic Chemistry and Applications. 2009. Vol. 2008, no. 2008, pp.1-5.
https://search.emarefa.net/detail/BIM-476547
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476547