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Circulating Antibodies to IDOTHO Pathway Metabolites in Alzheimer's Disease
Joint Authors
Sevin, F.
Mangas, Arturo
Geffard, Michel
Duleu, S.
Veyret, B.
Bessede, A.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In Alzheimer's disease, indoleamine 2,3-dioxygenase and tryptophan hydroxylase are known to induce an overproduction of neurotoxic compounds, such as quinolinic acid and 3-hydroxykynurenine from the former, and 5-hydroxytryptophol and 5-methoxytryptophol from the latter.
Other compounds, such as kynurenic acid, serotonin, and melatonin are produced via the same pathways.
An improved ELISA method identified circulating antibodies directed against these compounds, linked to proteins, as previously described for other chronic diseases.
This describes how only the A isotype of circulating immunoglobulins recognized a pattern of conjugated tryptophan metabolites in the sera of Alzheimer patients.
These data indirectly confirmed the involvement of tryptophan derivatives in the pathogenic processes of Alzheimer's disease.
Further studies are required to evaluate the relevance of these antibody patterns in monitoring this disease.
American Psychological Association (APA)
Duleu, S.& Mangas, Arturo& Sevin, F.& Veyret, B.& Bessede, A.& Geffard, Michel. 2010. Circulating Antibodies to IDOTHO Pathway Metabolites in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-476586
Modern Language Association (MLA)
Duleu, S.…[et al.]. Circulating Antibodies to IDOTHO Pathway Metabolites in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-476586
American Medical Association (AMA)
Duleu, S.& Mangas, Arturo& Sevin, F.& Veyret, B.& Bessede, A.& Geffard, Michel. Circulating Antibodies to IDOTHO Pathway Metabolites in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-476586
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476586