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The Endothelial ADMANO Pathway in Hypoxia-Related Chronic Respiratory Diseases
Joint Authors
Harbaum, Lars
Lüneburg, Nicole
Hennigs, Jan K.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Since its discovery, many adhere to the view that asymmetric dimethylarginine (ADMA), as an inhibitor of the synthesis of nitric oxide (NO), contributes to the pathogenesis of various diseases.
Particularly, this is evident in disease of the cardiovascular system, in which endothelial dysfunction results in an imbalance between vasoconstriction and vasodilatation.
Even if increased ADMA concentrations are closely related to an endothelial dysfunction, several studies pointed to a potential beneficial effect of ADMA, mainly in the context of angioproliferative disease such as cancer and fibrosis.
Antiproliferative properties of ADMA independent of NO have been identified in this context.
In particular, the regulation of ADMA by its degrading enzyme dimethylarginine dimethylaminohydrolase (DDAH) is the object of many studies.
DDAH is discussed as a promising therapeutic target for the indirect regulation of NO.
In hypoxia-related chronic respiratory diseases, this controversy discussion of ADMA and DDAH is particularly evident and is therefore subject of this review.
American Psychological Association (APA)
Lüneburg, Nicole& Harbaum, Lars& Hennigs, Jan K.. 2014. The Endothelial ADMANO Pathway in Hypoxia-Related Chronic Respiratory Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-476594
Modern Language Association (MLA)
Lüneburg, Nicole…[et al.]. The Endothelial ADMANO Pathway in Hypoxia-Related Chronic Respiratory Diseases. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-476594
American Medical Association (AMA)
Lüneburg, Nicole& Harbaum, Lars& Hennigs, Jan K.. The Endothelial ADMANO Pathway in Hypoxia-Related Chronic Respiratory Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-476594
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476594