T-Cell Traffic Jam in Hodgkin's Lymphoma : Pathogenetic and Therapeutic Implications
Joint Authors
Longinotti, Maurizio
Fozza, Claudio
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In hematologic malignancies, the microenvironment is often characterized by nonneoplastic cells with peculiar phenotypic and functional features.
This is particularly true in Hodgkin's lymphoma (HL), in which T lymphocytes surrounding Hodgkin's Reed-Sternberg cells are essentially polarized towards a memory T-helper type 2 phenotype.
In this paper we will first evaluate the main processes modulating T-cell recruitment towards the lymph node microenvironment in HL, especially focusing on the role played by cytokines.
We will then consider the most relevant mechanisms of immune escape exerted by neoplastic cells in order to evade antitumor immunity.
The potential pathogenetic and prognostic impact of regulatory T cells in such a context will be also described.
We will finally overview some of the strategies of cellular immunotherapy applied in patients with HL.
American Psychological Association (APA)
Fozza, Claudio& Longinotti, Maurizio. 2010. T-Cell Traffic Jam in Hodgkin's Lymphoma : Pathogenetic and Therapeutic Implications. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-476600
Modern Language Association (MLA)
Fozza, Claudio& Longinotti, Maurizio. T-Cell Traffic Jam in Hodgkin's Lymphoma : Pathogenetic and Therapeutic Implications. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-476600
American Medical Association (AMA)
Fozza, Claudio& Longinotti, Maurizio. T-Cell Traffic Jam in Hodgkin's Lymphoma : Pathogenetic and Therapeutic Implications. Advances in Hematology. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-476600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476600