Regulation of Bile Acid and Cholesterol Metabolism by PPARs
Joint Authors
Li, Tiangang
Chiang, John Y. L.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Bile acids are amphipathic molecules synthesized from cholesterol in the liver.
Bile acid synthesis is a major pathway for hepatic cholesterol catabolism.
Bile acid synthesis generates bile flow which is important for biliary secretion of free cholesterol, endogenous metabolites, and xenobiotics.
Bile acids are biological detergents that facilitate intestinal absorption of lipids and fat-soluble vitamins.
Recent studies suggest that bile acids are important metabolic regulators of lipid, glucose, and energy homeostasis.
Agonists of peroxisome proliferator-activated receptors (PPARα, PPARγ, PPARδ) regulate lipoprotein metabolism, fatty acid oxidation, glucose homeostasis and inflammation, and therefore are used as anti-diabetic drugs for treatment of dyslipidemia and insulin insistence.
Recent studies have shown that activation of PPARα alters bile acid synthesis, conjugation, and transport, and also cholesterol synthesis, absorption and reverse cholesterol transport.
This review will focus on the roles of PPARs in the regulation of pathways in bile acid and cholesterol homeostasis, and the therapeutic implications of using PPAR agonists for the treatment of metabolic syndrome.
American Psychological Association (APA)
Li, Tiangang& Chiang, John Y. L.. 2009. Regulation of Bile Acid and Cholesterol Metabolism by PPARs. PPAR Research،Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-476611
Modern Language Association (MLA)
Li, Tiangang& Chiang, John Y. L.. Regulation of Bile Acid and Cholesterol Metabolism by PPARs. PPAR Research No. 2009 (2009), pp.1-15.
https://search.emarefa.net/detail/BIM-476611
American Medical Association (AMA)
Li, Tiangang& Chiang, John Y. L.. Regulation of Bile Acid and Cholesterol Metabolism by PPARs. PPAR Research. 2009. Vol. 2009, no. 2009, pp.1-15.
https://search.emarefa.net/detail/BIM-476611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476611