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Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Lack of donor availability limits the number of human donor organs.
The need for host immunosuppression complicates transplantation procedures.
Ultrastructurally precise kidneys differentiate in situ following xenotransplantation in mesentery of embryonic pig renal primordia.
The developing organ attracts its blood supply from the host, obviating humoral rejection.
Engraftment of pig renal primordia transplanted directly into rats requires host immune suppression.
However, insulin-producing cells originating from embryonic pig pancreas obtained very early following initiation of organogenesis [embryonic day 28 (E28)] engraft long term in nonimmune-suppressed diabetic rats or rhesus macaques.
Engraftment of morphologically similar cells originating from adult porcine islets of Langerhans (islets) occurs in rats previously transplanted with E28 pig pancreatic primordia.
Here, we review recent findings germane to xenotransplantation of pig renal or pancreatic primordia as a novel organ replacement strategy.
American Psychological Association (APA)
Hammerman, Marc R.. 2010. Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476612
Modern Language Association (MLA)
Hammerman, Marc R.. Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs. Journal of Transplantation No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-476612
American Medical Association (AMA)
Hammerman, Marc R.. Xenotransplantation of Embryonic Pig Kidney or Pancreas to Replace the Function of Mature Organs. Journal of Transplantation. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476612