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Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds
Joint Authors
Duek, Eliana Aparecida de Rezende
Messias, André Dutra
Motta, Adriana Cristina
Martins, Kelly Fernanda
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Lactide-based polymers have been widely investigated as materials for tissue engineering.
However, characteristics such as low flexibility and elongation tend to limit particular applications, although these can be enhanced by adding plasticizers such as trimethylene carbonate (TMC) to the polymer chain of the copolymer poly(L-lactide-co-D,L-lactide) (PLDLA).
The aim of this work was to synthesize and characterize a terpolymer of L-lactide, D,L-lactide, and TMC.
The polymers were synthesized from 30% TMC by bulk polymerization and resulted in an average molar mass >105 g/mol.
Thermal investigation of PLDLA-TMC showed a decrease in the glass transition and onset temperatures compared to PLDLA.
PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts.
These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC.
Scaffolds of this terpolymer had important characteristics that could be useful for applications in bone tissue engineering.
American Psychological Association (APA)
Messias, André Dutra& Martins, Kelly Fernanda& Motta, Adriana Cristina& Duek, Eliana Aparecida de Rezende. 2014. Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476618
Modern Language Association (MLA)
Messias, André Dutra…[et al.]. Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds. International Journal of Biomaterials No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-476618
American Medical Association (AMA)
Messias, André Dutra& Martins, Kelly Fernanda& Motta, Adriana Cristina& Duek, Eliana Aparecida de Rezende. Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476618