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Secondary Structure Preferences of Mn2+ Binding Sites in Bacterial Proteins
Author
Khrustaleva, Tatyana Aleksandrovna
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
3D structures of proteins with coordinated Mn2+ ions from bacteria with low, average, and high genomic GC-content have been analyzed (149 PDB files were used).
Major Mn2+ binders are aspartic acid (6.82% of Asp residues), histidine (14.76% of His residues), and glutamic acid (3.51% of Glu residues).
We found out that the motif of secondary structure “beta strand-major binder-random coil” is overrepresented around all the three major Mn2+ binders.
That motif may be followed by either alpha helix or beta strand.
Beta strands near Mn2+ binding residues should be stable because they are enriched by such beta formers as valine and isoleucine, as well as by specific combinations of hydrophobic and hydrophilic amino acid residues characteristic to beta sheet.
In the group of proteins from GC-rich bacteria glutamic acid residues situated in alpha helices frequently coordinate Mn2+ ions, probably, because of the decrease of Lys usage under the influence of mutational GC-pressure.
On the other hand, the percentage of Mn2+ sites with at least one amino acid in the “beta strand-major binder-random coil” motif of secondary structure (77.88%) does not depend on genomic GC-content.
American Psychological Association (APA)
Khrustaleva, Tatyana Aleksandrovna. 2014. Secondary Structure Preferences of Mn2+ Binding Sites in Bacterial Proteins. Advances in Bioinformatics،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-476626
Modern Language Association (MLA)
Khrustaleva, Tatyana Aleksandrovna. Secondary Structure Preferences of Mn2+ Binding Sites in Bacterial Proteins. Advances in Bioinformatics No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-476626
American Medical Association (AMA)
Khrustaleva, Tatyana Aleksandrovna. Secondary Structure Preferences of Mn2+ Binding Sites in Bacterial Proteins. Advances in Bioinformatics. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-476626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476626