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Convulsive and Neurodegenerative Effects in Rats of Some Isolated Toxins from the Tityus bahiensis Scorpion Venom
Joint Authors
Takeishi Ossanai, Luciene Toshie
Coronado Dorce, Valquiria Abrão
Lourenço, Geane Antiques
Abrahão Nencioni, Ana Leonor
Lebrun, Ivo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Biology
Medicine
Abstract EN
Despite Tityus bahiensis being one of the most dangerous scorpions in Brazil, there are few studies about the effects of its venom, which acts mainly on the central nervous system.
Previous studies demonstrated the convulsive ability of this venom.
The present work aimed to study the hippocampal effects in rats of some toxins isolated from pool V, which induces a pronounced epileptogenic effect.
The pool was separated by reverse-phase HPLC, and the peaks with higher yield (Tb V-1, V-5, V-24, V-27, and V-28) were used in the experiments.
Cannulae and electrodes were implanted in the hippocampus of male Wistar rats (240–250 g).
The animals were divided into six groups that received intracerebral injection of toxin solution (1 or 2 μg/μL) or Ringer solution (control group), and they were submitted to behavioral, electrographic, and histological analysis.
All toxins studied evoked electrographic and behavioral epileptic-like activity to different degrees.
Moreover, the toxins V-1, V-24, and V-28 caused significant neuronal loss in CA4 ipsi- and contralateral hippocampal areas.
These results suggest that toxins from T.
bahiensis scorpion, when injected into the hippocampus, are able to act directly on the central nervous system inducing convulsive and neurodegenerative effects.
American Psychological Association (APA)
Takeishi Ossanai, Luciene Toshie& Lourenço, Geane Antiques& Lebrun, Ivo& Abrahão Nencioni, Ana Leonor& Coronado Dorce, Valquiria Abrão. 2013. Convulsive and Neurodegenerative Effects in Rats of Some Isolated Toxins from the Tityus bahiensis Scorpion Venom. Journal of Toxins،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476632
Modern Language Association (MLA)
Takeishi Ossanai, Luciene Toshie…[et al.]. Convulsive and Neurodegenerative Effects in Rats of Some Isolated Toxins from the Tityus bahiensis Scorpion Venom. Journal of Toxins No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476632
American Medical Association (AMA)
Takeishi Ossanai, Luciene Toshie& Lourenço, Geane Antiques& Lebrun, Ivo& Abrahão Nencioni, Ana Leonor& Coronado Dorce, Valquiria Abrão. Convulsive and Neurodegenerative Effects in Rats of Some Isolated Toxins from the Tityus bahiensis Scorpion Venom. Journal of Toxins. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476632
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476632