MMP-2 and sTNF-R1 Variability in Patients with Essential Hypertension : 1-Year Follow-Up Study

Abstract EN

The aim of this study is to analyze MMP-2 and sTNF-R1 variability, potent predictors of cardiovascular events, in stable hypertensive patients during a 12-month followup.

234 asymptomatic patients (age 60±13, 136 male) out of 252 patients with essential hypertension were followed up.

MMP-2 and sTNF-R1 were measured at baseline and after 12 months (stage I).

To compare MMP-2 and sTNF-R1 levels over time interval, we used the statistical method of Bland-Altman.

MMP-2 and sTNF-R1 reproducibility was good in our patients for the two intervals with a coefficient of reproducibility of 8.2% and 11.3%, respectively.

The percentages of patients within 1.96 × standard deviation of the mean were 93.6% and 92.7%.

An elevated coefficient of correlation was obtained for MMP-2, basal versus stage I (r=0.55, P<0.0001) and for sTNF-R1 (r=0.75, P<0.0001).

There is good stability in MMP-2 and sTNF-R1 levels in a followup study of patients with stable hypertension.

As a consequence, assessment of its concentrations may be a useful tool for monitoring the follow-up of these patients.

Measured variations in MMP-2 and sTNF-R1 levels, exceeding 8.2% and 11.3%, respectively, may indicate an increase in cardiovascular risk, thus, could be used to optimizing treatment than blood pressure control alone.