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Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter : Premalignant Lesions or Preinvasive Cancer?
Joint Authors
Fortunato, Lucio
Mauri, Maria
Campagna, Domenico
Costarelli, Leopoldo
Source
International Journal of Surgical Oncology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Morphological criteria for the diagnosis of intraductal proliferative lesions of the breast have been an object of research and much controversy, and its terminology is rather confusing.
Knowledge of the molecular aspects of this disease probably necessitates further research to clarify if these entities can be identified as breast cancer precursors or as a malignant preinvasive disease.
These issues are of great interest not only for their biological implications, but also to the clinician who must understand the disease and direct therapies.
Molecular studies have shown that epitheliosis (usual ductal hyperplasia) is not monoclonal, while malignant lesions (atypical ductal hyperplasia, flat epithelial atypia, low-grade and high-grade intraductal carcinoma) constantly show these characteristics.
These malignant lesions, classified with a DIN grading system (ductal intraepithelial neoplasia), are not obligate precursors of invasive ductal carcinoma and do not represent different evolving grades in a linear model of cancerogenesis.
Breast cancerogenesis probably has different pathways with different morphologic precursors.
American Psychological Association (APA)
Costarelli, Leopoldo& Campagna, Domenico& Mauri, Maria& Fortunato, Lucio. 2012. Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter : Premalignant Lesions or Preinvasive Cancer?. International Journal of Surgical Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-476637
Modern Language Association (MLA)
Costarelli, Leopoldo…[et al.]. Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter : Premalignant Lesions or Preinvasive Cancer?. International Journal of Surgical Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-476637
American Medical Association (AMA)
Costarelli, Leopoldo& Campagna, Domenico& Mauri, Maria& Fortunato, Lucio. Intraductal Proliferative Lesions of the Breast—Terminology and Biology Matter : Premalignant Lesions or Preinvasive Cancer?. International Journal of Surgical Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-476637
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476637