Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression : Synergy between TGF-β and IGF Signaling
Joint Authors
Zhang, Qiang
Rahmatpanah, Farah
McClelland, Michael
Zi, Xiaolin
Lee, Chung
Jia, Zhenyu
Mercola, Dan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This review postulates the role of transforming growth factor-beta (TGF-β) and insulin-like growth factor (IGF-I/IGF-II) signaling in stromal cells during prostate carcinogenesis and progression.
It is known that stromal cells have a reciprocal relationship to the adjacent epithelial cells in the maintenance of structural and functional integrity of the prostate.
An interaction between TGF-β and IGF signaling occupies a central part in this stromal-epithelial interaction.
An increase in TGF-β and IGF signaling will set off the imbalance of this relationship and will lead to cancer development.
A continuous input from TGF-β and IGF in the tumor microenvironment will result in cancer progression.
Understanding of these events can help prevention, diagnosis, and therapy of prostate cancer.
American Psychological Association (APA)
Lee, Chung& Jia, Zhenyu& Rahmatpanah, Farah& Zhang, Qiang& Zi, Xiaolin& McClelland, Michael…[et al.]. 2014. Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression : Synergy between TGF-β and IGF Signaling. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-476662
Modern Language Association (MLA)
Lee, Chung…[et al.]. Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression : Synergy between TGF-β and IGF Signaling. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-476662
American Medical Association (AMA)
Lee, Chung& Jia, Zhenyu& Rahmatpanah, Farah& Zhang, Qiang& Zi, Xiaolin& McClelland, Michael…[et al.]. Role of the Adjacent Stroma Cells in Prostate Cancer Development and Progression : Synergy between TGF-β and IGF Signaling. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-476662
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476662