Motor Cortex Stimulation in Parkinson's Disease
Joint Authors
Guzzi, Giusy
Romano, Mary
Volpentesta, Giorgio
Lavano, Serena Marianna
Bosco, Domenico
Lavano, Angelo
De Rose, Marisa
Plastino, Massimiliano
Marotta, Rosa
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-08
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain Stimulation (DBS) in Parkinson's disease.
However, it might be proposed to patients excluded from DBS or unresponsive to DBS.
Ten patients with advanced PD underwent unilateral MCS contralaterally to the worst clinical side.
A plate electrode was positioned over the motor cortex in the epidural space through single burr hole after identification of the area with neuronavigation and neurophysiological tests.
Clinical assessment was performed by total UPDRS, UPDRS III total, UPDRS III-items 27–31, UPDRS IV, and UPDRS II before implantation in off-medication and on-medication states and after surgery at 1, 3, 6, 12, 18, 24, and 36 months in on-medication/on-stimulation and off-medication/on-stimulation states.
We assessed changes of quality of life, throughout the Parkinson's disease quality of life scale (PDQoL-39), and the dose of anti-Parkinson's disease medications, throughout the Ldopa equivalent daily dose (LEDD).
During off-medication state, we observed moderate and transitory reduction of total UPDRS and UPDRS total scores and significant and long-lasting improvement in UPDRS III items 27–31 score for axial symptoms.
There was marked reduction of UPDRS IV score and LEDD.
PDQL-39 improvement was also significant.
No important complications and adverse events occurred.
American Psychological Association (APA)
De Rose, Marisa& Guzzi, Giusy& Bosco, Domenico& Romano, Mary& Lavano, Serena Marianna& Plastino, Massimiliano…[et al.]. 2012. Motor Cortex Stimulation in Parkinson's Disease. Neurology Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-476663
Modern Language Association (MLA)
De Rose, Marisa…[et al.]. Motor Cortex Stimulation in Parkinson's Disease. Neurology Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-476663
American Medical Association (AMA)
De Rose, Marisa& Guzzi, Giusy& Bosco, Domenico& Romano, Mary& Lavano, Serena Marianna& Plastino, Massimiliano…[et al.]. Motor Cortex Stimulation in Parkinson's Disease. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-476663
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476663