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Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form
Joint Authors
Baldania, Sunil L.
Chhalotiya, Usmangani K.
Parmar, Kaminee
Shah, Dimal A.
Parmar, Naimin
Source
International Journal of Spectroscopy
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A simple, precise, accurate, and economical spectrophotometric method has been developed for simultaneous estimation of levocetirizine dihydrochloride (LCT) and phenylephrine hydrochloride (PHE) by employing first-order derivative spectrophotometric method.
The first-order derivative absorption at 240 nm (zero crossing point of PHE) was used for quantification of LCT and 283.2 nm (zero crossing point of LCT) for quantification of PHE.
The linearity was established over the concentration range of 4–24 μg/mL and 8–48 μg/mL for LCT and PHE with correlation coefficients (r2) 0.9964 and 0.9972, respectively.
The mean % recoveries were found to be in the range of 99.14%–100.43% for LCT and 98.73%–100.83% for PHE.
The proposed method has been validated as per ICH guideline and successfully applied for the simultaneous estimation of LCT and PHE in combined tablet dosage form.
American Psychological Association (APA)
Parmar, Kaminee& Baldania, Sunil L.& Shah, Dimal A.& Chhalotiya, Usmangani K.& Parmar, Naimin. 2013. Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form. International Journal of Spectroscopy،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476677
Modern Language Association (MLA)
Parmar, Kaminee…[et al.]. Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form. International Journal of Spectroscopy No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-476677
American Medical Association (AMA)
Parmar, Kaminee& Baldania, Sunil L.& Shah, Dimal A.& Chhalotiya, Usmangani K.& Parmar, Naimin. Development and Validation of First-Order Derivative Spectrophotometry for Simultaneous Determination of Levocetirizine Dihydrochloride and Phenylephrine Hydrochloride in Pharmaceutical Dosage Form. International Journal of Spectroscopy. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-476677
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476677