Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process
Joint Authors
Zhang, Hongzhou
Movia, Dania
Leblanc, Roger M.
Li, Wenzhi
Thakur, Garima
Yang, Yuehai
Micic, Miodrag
Giordani, Silvia
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Nanoparticles have enormous potential in diagnostic and therapeutic studies.
We have demonstrated that the amyloid beta mixed with and conjugated to dihydrolipoic acid- (DHLA) capped CdSe/ZnS quantum dots (QDs) of size approximately 2.5 nm can be used to reduce the fibrillation process.
Transmission electron microscopy (TEM) and atomic force microscopy (AFM) were used as tools for analysis of fibrillation.
There is a significant change in morphology of fibrils when amyloid β (1–42) (Aβ (1–42)) is mixed or conjugated to the QDs.
The length and the width of the fibrils vary under modified conditions.
Thioflavin T (ThT) fluorescence supports the decrease in fibril formation in presence of DHLA-capped QDs.
American Psychological Association (APA)
Thakur, Garima& Micic, Miodrag& Yang, Yuehai& Li, Wenzhi& Movia, Dania& Giordani, Silvia…[et al.]. 2011. Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-476687
Modern Language Association (MLA)
Thakur, Garima…[et al.]. Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-476687
American Medical Association (AMA)
Thakur, Garima& Micic, Miodrag& Yang, Yuehai& Li, Wenzhi& Movia, Dania& Giordani, Silvia…[et al.]. Conjugated Quantum Dots Inhibit the Amyloid β (1–42) Fibrillation Process. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-476687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476687