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Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma
Joint Authors
Maeda, Tetsuo
Takeuchi, Nobuhiro
Naba, Kazuyoshi
Yusuke, Nomura
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
A 69-year-old female presented to our institution with epigastralgia and abdominal distension.
Upper gastrointestinal series revealed a 5 cm ulcerative lesion with irregular margins and elevated distinct borders from the angle to the pyloric ring.
Gastroendoscopy revealed a Borrmann type 2 tumor.
Several biopsied specimens revealed proliferation of small and heterogeneous cancer cells with rich chromatin and fibrous septum with rich vessels at connective tissues, which was confirmed as gastric endocrine cell carcinoma (ECC) on immunostaining with chromogranin and synaptophysin.
Furthermore, other specimens revealed atypical cells forming glandular structures, which were confirmed as well-differentiated tubular adenocarcinomas.
Distal gastrectomy with D2 lymph node dissection and Billroth I reconstruction was performed.
Pathological examination of the gross specimen revealed that adenocarcinoma comprised <10% of all cancer cells.
Close analysis of ECC revealed a mixture of small and large cells.
According to the WHO 2010 classification of gastrointestinal neuroendocrine tumors, this gastric tumor was diagnosed as neuroendocrine carcinoma.
The patient was administered adjuvant chemotherapy with cisplatin and etoposide.
One year following surgery, follow-up abdominal CT revealed multiple liver metastases.
The patient received the best supportive care but eventually died 18 months after surgery.
Here we present this case of gastric ECC coexistent with adenocarcinoma.
American Psychological Association (APA)
Takeuchi, Nobuhiro& Yusuke, Nomura& Maeda, Tetsuo& Naba, Kazuyoshi. 2013. Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-476693
Modern Language Association (MLA)
Takeuchi, Nobuhiro…[et al.]. Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma. Case Reports in Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-476693
American Medical Association (AMA)
Takeuchi, Nobuhiro& Yusuke, Nomura& Maeda, Tetsuo& Naba, Kazuyoshi. Gastric Endocrine Cell Carcinoma Coexistent with Adenocarcinoma. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-476693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476693