Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease
Joint Authors
Berlanga, Alba
Martinez, Salomé
Alibalic, Ajla
Auguet, Teresa
Del Castillo, Daniel
Terra, Ximena
Aguilar, Carmen
Sabench, Fàtima
Hernández, Mercé
Guiu-Jurado, Esther
Filiu, Elisa
Richart, Cristóbal
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Recent reports suggest a role for the endocannabinoid system in the pathology of nonalcoholic fatty liver disease (NAFLD).
The aim of this study was to investigate the relationship between liver expression of cannabinoid (CB) receptor subtypes, CB1 and CB2, in morbidly obese (MO) women with different histological stages of NAFLD.
Methods.
We analysed hepatic CB1 and CB2 mRNA expression, and the expression of genes involved in lipid metabolism in 72 MO women, subclassified by liver histology into MO with normal liver (NL, n=16), simple steatosis (SS, n=28), and nonalcoholic steatohepatitis (NASH, n=28) by enzyme-linked immunosorbent assay and RT-PCR.
Results.
We found that CB1 mRNA expression was significantly higher in NASH compared with SS and correlated negatively with PPARα.
Regarding CB2, CB2 mRNA expression correlated positively with ACC1, PPARγ, IL6, TNFα, resistin, and adiponectin.
Conclusions.
The increased expression of CB1 in NASH and the negative correlation with PPARα suggest a deleterious role of CB1 in NAFLD.
Regarding CB2, its positive correlation with the anti-inflammatory molecule adiponectin and, paradoxically, with inflammatory genes suggests that this receptor has a dual role.
Taken together, our results suggest that endocannabinoid receptors might be involved in the pathogenesis of NAFLD, a finding which justifies further study.
American Psychological Association (APA)
Auguet, Teresa& Berlanga, Alba& Guiu-Jurado, Esther& Terra, Ximena& Martinez, Salomé& Aguilar, Carmen…[et al.]. 2014. Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476698
Modern Language Association (MLA)
Auguet, Teresa…[et al.]. Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-476698
American Medical Association (AMA)
Auguet, Teresa& Berlanga, Alba& Guiu-Jurado, Esther& Terra, Ximena& Martinez, Salomé& Aguilar, Carmen…[et al.]. Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476698
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476698