Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice
Joint Authors
Jiang, Jian
Jin, Wei
Lu, Tianyu
Ni, Hongbin
Wu, Jun
Dai, Yuxiang
Wang, Handong
Liang, Weibang
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Traumatic brain injury (TBI) can induce intestinal inflammatory response and mucosal injury.
Antioxidant transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown in our previous studies to prevent oxidative stress and inflammatory response in gut after TBI.
The objective of this study was to test whether tert-butylhydroquinone (tBHQ), an Nrf2 inducer, can protect against TBI-induced intestinal inflammatory response and mucosal injury in mice.
Adult male ICR mice were randomly divided into three groups: (1) sham + vehicle group, (2) TBI + vehicle group, and (3) TBI + tBHQ group (n=12 per group).
Closed head injury was adopted using Hall's weight-dropping method.
Intestinal mucosa apoptosis and inflammatory-related factors, such as nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and intercellular adhesion molecule-1 (ICAM-1), were investigated at 24 h after TBI.
As a result, we found that oral treatment with 1% tBHQ prior to TBI for one week markedly decreased NF-κB activation, inflammatory cytokines production, and ICAM-1 expression in the gut.
Administration of tBHQ also significantly attenuated TBI-induced intestinal mucosal apoptosis.
The results of the present study suggest that tBHQ administration could suppress the intestinal inflammation and reduce the mucosal damage following TBI.
American Psychological Association (APA)
Jin, Wei& Ni, Hongbin& Dai, Yuxiang& Wang, Handong& Lu, Tianyu& Wu, Jun…[et al.]. 2011. Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-476700
Modern Language Association (MLA)
Jin, Wei…[et al.]. Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice. Mediators of Inflammation No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-476700
American Medical Association (AMA)
Jin, Wei& Ni, Hongbin& Dai, Yuxiang& Wang, Handong& Lu, Tianyu& Wu, Jun…[et al.]. Effects of Tert-Butylhydroquinone on Intestinal Inflammatory Response and Apoptosis following Traumatic Brain Injury in Mice. Mediators of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-476700
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476700