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Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis
Joint Authors
Todorov, Todor
Monova, Daniela
Monov, Simeon
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
The new ISN/RPS classification of lupus nephritis (LN) divides diffuse proliferative LN into two subcategories with predominantly segmental proliferative lesions (class IV-S) and with predominantly global proliferative lesions (class IV-G).
This paper explores the validity of this distinction and possible differences between the two types of lesions.
Patients and Methods.
A retrospective analysis of biopsy-proven cohort of 231 patients with LN was performed.
Clinical and laboratory data were available on all patients selected.
Results.
The prevalence of Class IV was 27,27% (41 patients had class IV-S, 22-class IV-G).
The serum creatinine levels, proteinuria, and diastolic blood pressure were significantly greater in the IV-G class, but haemoglobin was significantly lower.
Histologically combined lesions with segmental endocapillary proliferation and fibrinoid necrosis were more frequent in the class IV-S.
No significant difference was detected in outcomes in the two groups after followups of 145,2 ± 76,87 months.
Conclusions.
There are definite clinical and morphologic differences between class IV-S and IV-G lesions.
Data suggest that class IV-G lesions behave as an immune complex disease; however, in class IV-S lesions, the presence of proportionally greater glomerular fibrinoid necroses suggests that these lesions may have a different pathogenesis.
American Psychological Association (APA)
Monova, Daniela& Monov, Simeon& Todorov, Todor. 2011. Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis. ISRN Immunology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-476703
Modern Language Association (MLA)
Monova, Daniela…[et al.]. Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis. ISRN Immunology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-476703
American Medical Association (AMA)
Monova, Daniela& Monov, Simeon& Todorov, Todor. Clinical and Morphologic Differences between Class IV-S and Class IV-G Lupus Nephritis. ISRN Immunology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-476703
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476703