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The Impact of Autophagy on Cell Death Modalities
Joint Authors
Choi, Augustine M. K.
Mizumura, Kenji
Ryter, Stefan W.
Source
International Journal of Cell Biology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Autophagy represents a homeostatic cellular mechanism for the turnover of organelles and proteins, through a lysosome-dependent degradation pathway.
During starvation, autophagy facilitates cell survival through the recycling of metabolic precursors.
Additionally, autophagy can modulate other vital processes such as programmed cell death (e.g., apoptosis), inflammation, and adaptive immune mechanisms and thereby influence disease pathogenesis.
Selective pathways can target distinct cargoes (e.g., mitochondria and proteins) for autophagic degradation.
At present, the causal relationship between autophagy and various forms of regulated or nonregulated cell death remains unclear.
Autophagy can occur in association with necrosis-like cell death triggered by caspase inhibition.
Autophagy and apoptosis have been shown to be coincident or antagonistic, depending on experimental context, and share cross-talk between signal transduction elements.
Autophagy may modulate the outcome of other regulated forms of cell death such as necroptosis.
Recent advances suggest that autophagy can dampen inflammatory responses, including inflammasome-dependent caspase-1 activation and maturation of proinflammatory cytokines.
Autophagy may also act as regulator of caspase-1 dependent cell death (pyroptosis).
Strategies aimed at modulating autophagy may lead to therapeutic interventions for diseases in which apoptosis or other forms of regulated cell death may play a cardinal role.
American Psychological Association (APA)
Ryter, Stefan W.& Mizumura, Kenji& Choi, Augustine M. K.. 2014. The Impact of Autophagy on Cell Death Modalities. International Journal of Cell Biology،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-476711
Modern Language Association (MLA)
Ryter, Stefan W.…[et al.]. The Impact of Autophagy on Cell Death Modalities. International Journal of Cell Biology No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-476711
American Medical Association (AMA)
Ryter, Stefan W.& Mizumura, Kenji& Choi, Augustine M. K.. The Impact of Autophagy on Cell Death Modalities. International Journal of Cell Biology. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-476711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476711