Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell Development
Joint Authors
Pérez-Vera, Patricia
Fuentes-Pananá, Ezequiel M.
Reyes-León, Adriana
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
B cell development starts in bone marrow with the commitment of hematopoietic progenitors to the B cell lineage.
In murine models, the IL-7 and preBCR receptors, and the signaling pathways and transcription factors that they regulate, control commitment and maintenance along the B cell pathway.
E2A, EBF1, PAX5, and Ikaros are among the most important transcription factors controlling early development and thereby conditioning mice homeostatic B cell lymphopoiesis.
Importantly, their gain or loss of function often results in malignant development in humans, supporting conserved roles for these transcription factors.
B cell acute lymphoblastic leukemia is the most common cause of pediatric cancer, and it is characterized by unpaired early B cell development resulting from genetic lesions in these critical signaling pathways and transcription factors.
Fine mapping of these genetic abnormalities is allowing more specific treatments, more accurately predicting risk profiles for this disease, and improving survival rates.
American Psychological Association (APA)
Pérez-Vera, Patricia& Reyes-León, Adriana& Fuentes-Pananá, Ezequiel M.. 2011. Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell Development. Bone Marrow Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-476725
Modern Language Association (MLA)
Pérez-Vera, Patricia…[et al.]. Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell Development. Bone Marrow Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-476725
American Medical Association (AMA)
Pérez-Vera, Patricia& Reyes-León, Adriana& Fuentes-Pananá, Ezequiel M.. Signaling Proteins and Transcription Factors in Normal and Malignant Early B Cell Development. Bone Marrow Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-476725
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476725