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Methylation Markers for Urine-Based Detection of Bladder Cancer : The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-18
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Cancer of the urinary bladder is the fifth most common neoplasm in the industrialized countries.
Diagnosis and surveillance are dependent on invasive evaluation with cystoscopy and to some degree cytology as an adjunct analysis.
Nomuscle invasive bladder cancer is characterized by frequent recurrences after resection, and up to 30% will develop an aggressive phenotype.
The journey towards a noninvasive test for diagnosing bladder cancer, in order to replace or extend time between cystoscopy, has been ongoing for more than a decade.
However, only a handful of tests that aid in clinical decision making are commercially available.
Recent reports of DNA methylation in urine specimens highlight a possible clinical use of this marker type, as high sensitivities and specificities have been shown.
This paper will focus on the currently available markers NMP22, ImmunoCyt, and UroVysion as well as novel DNA methylation markers for diagnosis and surveillance of bladder cancer.
American Psychological Association (APA)
Reinert, Thomas. 2012. Methylation Markers for Urine-Based Detection of Bladder Cancer : The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer. Advances in Urology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476778
Modern Language Association (MLA)
Reinert, Thomas. Methylation Markers for Urine-Based Detection of Bladder Cancer : The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer. Advances in Urology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-476778
American Medical Association (AMA)
Reinert, Thomas. Methylation Markers for Urine-Based Detection of Bladder Cancer : The Next Generation of Urinary Markers for Diagnosis and Surveillance of Bladder Cancer. Advances in Urology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476778